Genes that could increase the risk of fractures in horses
New study from Great Britain
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A research team from the Royal Veterinary College (RVC) has identified 112 genes that could influence the risk of bone fractures in Thoroughbreds. These findings should help to better understand genetic risk factors and develop targeted measures to reduce fractures.
Under the direction of Dr. Debbie Guest, the scientists used stem cells from horses with varying degrees of fracture risk to generate bone-forming cells and examine their gene expression. This revealed that many of these genes are involved in the regulation of the bone matrix, while some had not been studied in this context before.
An earlier study has already shown that collagen type III, which is essential for normal bone formation, is produced in lower quantities in horses with an increased risk of fracture. Future research should uncover further genetic mechanisms in order to develop new preventive measures and treatment strategies.